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[9001766.] كود البحث : 9001766 - 2017/11/26
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Measurement of some Tumor Markers in Ovarian cancer by Flow Cytometry /
تخصص البحث : Basic Sciences
  Mansoura Journal of Environmental Sciences - Egypt JOESE / Vol.46 No. 2 - June2017
  Magdy M. Youssef - مؤلف رئيسي
  Sameh R. Abd El-Aziz
  Mona S. Gouida
  Aya G. Elwan
  Keywords:
Ovarian cancer
Cancer antigen 125
Cell cycle
  Abstract
Ovarian cancer is among the most lethal types of reproductive system tumors and a
leading cause of cancer-related deaths in women globally cancer antigen125 (CA125)
is the most widely used tumor marker in ovarian cancer. It is elevated in about 80% of
women with epithelial with early stage of disease. Flow cytometric analysis of cell cycle
measures the apoptotic changes in cells by staining them with DNA dyes. In this
study, we aimed to measure level of CA125, liver function test and complete blood
count by biochemical and haematological methods. Cell cycle is analyzed by flow cytometry
in epithelial ovarian cancer and benign diseases.
The results showed that, the level of CA 125 is significantly increased in malignant
group than in normal and bengin groups (P = 0.001). The level of liver function which
include serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic
transaminase (SGPT), albumin and bilirubin is significantly increased in malignant
group than in normal and benign group. The count of WBCS, RBCS and hemoglobin
levels is decreased but that of platelets count is increased in malignant than in normal
and benign groups. Sub-G1 apoptotic level is statistically significantly decreased in benign
and malignant group than that in normal group (P = 0.001). Also, The data showed
that S phase level had statistically significant increased in malignant group than that in
the normal group (P= 0.001). This study explained the changes in sub-G1 apoptosis for
normal and benign groups that was increased significantly than that in the malignant
group level.
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